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Therefore, combining WD with MC4R-KO mice, which exhibit substantial obesity and insulin resistance 21 , is an attractive MASH model with considerable fibrosis compared to the DIO mouse model

Palmitoleic acid is elevated in fatty liver disease and reflects hepatic lipogenesis

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Notably, the cytoplasmic C-terminal tail of ZnT1 alone can inhibit the channel, suggesting that the inhibition of L-type calcium channels by ZnT1 is independent of zinc channel function